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SSRIs block serotonin transporter (SERT) increasing levels of serotonin. The main receptors serotonin acts on are 5HT2A, 5HT2C, 5HT3 and 5HT1A autoreceptor. The initial activation of the post-synaptic 5HT2A, 5HT2C and 5HT3 receptors are responsible for side effects. These receptors downregulate in 1-2 weeks and the side effects wane. The 5HT1A receptor also downregulates after a lag of 2-4 weeks (onset of action for SSRIs) which results in serotonin flowing down the presynaptic neuron and the neuron firing.

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